The Regulatory Genome In Adaptation , Evolution , Development And Disease (Original PDF From Publisher)

The Regulatory Genome In Adaptation , Evolution , Development And Disease (Original PDF From Publisher)

Written by Moyra Smith

The Role of the Regulatory Genome in Development, Evolution and Illness summarizes findings from contemporary genomic

and gene expression research on a variety of taxa, including humans, plants, animals, and single cells.

It also looks at the shared functions that gene regulation plays in developmental biology, susceptibility to disease and

adaptive evolution.

The book clarifies gene regulation over evolutionary timeframes, opening up new research directions and fields of study.

The main topics covered in each chapter include the basics of genomic changes over time and in response to environmental

and local factors, epigenetics in adaptive evolution, and adaptive gene regulation in developmental biology, disease

biology and healthy processes.

In order to highlight shared evolutionary themes and genomic diversity uncovered by recent sequencing and GWAS investigations

, as well as how this influences our knowledge of human adaptive evolution, a comparative approach is used throughout

the book across organisms.

The book concludes by describing how we might apply this information to influence human metabolism, development

and physiology in a healthy way as well as the results of disease.

outlines the essential components of gene expression control and the methods used to investigate gene regulation over

evolutionary timescales.

takes a cross-species perspective, combining recent sequencing and GWAS findings from several creatures to reveal new

insights and point the way for further investigation.

takes into account changed gene expression linked to diseases and developmental abnormalities, as well as normal biology

and physiology and our ability to adapt to illness