Neuroimmune Interactions in Pain : Mechanisms and Therapeutics (Original PDF from Publisher)

Neuroimmune Interactions in Pain : Mechanisms and Therapeutics (Original PDF from Publisher)

By Jasmine Ji , Jianguo Cheng, and Ru-Rong Ji

More people worldwide are experiencing chronic pain as lifespans lengthen . Despite this, there are still just a few very limited therapy choices available .

Anti-inflammatory medications have limited efficacy and opiate painkillers have resulted in devastating addictions and lethal overdoses . The involvement of immune cells , including glial cells and neuroimmune interactions in chronic pain are the focus of the book . The first section of the book looks at the preclinical and clinical data that non-neuronal cells are involved in chronic pain . It talks about how non-neuronal cells and neurons interact to control chronic pain .

The implications of these findings are then discussed , including promising and emerging therapies like immune cell therapy , neuromodulation and regenerative medicine , as well as specialized pro-resolving mediators (SPMs, such as resolvins and protectins) , which may prove to be the turning point for hundreds of millions of patients worldwide who struggle to overcome chronic pain . The groundbreaking findings presented in this book will challenge popular notions about chronic pain .

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