TRiPs Across Epithelial And Endothelial Barriers In Health And Disease (Original PDF From Publisher)

TRiPs Across Epithelial And Endothelial Barriers In Health And Disease (Original PDF From Publisher)

Author: Nova Medicine and Health

The earliest primordial prokaryotes on Earth were able to survive in isolation from their harsh surroundings some 4 billion years ago,

marking the beginning of life as we know it today.

These early life forms’ immediate challenge was striking the best possible balance between two seemingly incompatible tasks:

protecting themselves from the extracellular milieu and separating from it and efficiently exchanging ions, energy sources and

metabolites with the same milieu.

Early evolutionary progress had to deal with even more difficult issues, like how to assign certain cell functions to distinct internal

structures called organelles (like the nucleus) and, in the case of multicellular organisms, how to properly separate various cell types

(like those found in various tissues and organs) while maintaining effective communication between them.

The human body is actually highly segmented, from the level of individual cells, where local signals are produced and spread in an

extremely organized fashion, to the level of the entire body.

The purpose of this work is to acquaint the interested reader with the world of these intricately divided compartments in mammals.

It goes over how various barrier types, such as endothelium and epithelial, typically retain their integrity as well as what might happen

when their permeability is unusually low or excessive in certain disease situations.

We’ll concentrate on a few of these obstacles because they’ve been thoroughly researched and are essential to overall health.

We shall pay close attention to the endometrial, intestinal barrier, skin, respiratory and urine systems.

Transient Receptor Potential channels, in particular, are among the most innovative classes of prospective molecular candidates that

will be specifically mentioned throughout the book as potential solutions for barrier-related dysfunctions.

As a result, the book’s title has three meanings : translating research into practice (TRIP), a trip in the traditional sense and TRP

channels (like in the TRiP database).

Physiologists, pharmacologists, biophysicists and physicians make up our team of writers.

Among them is the national representative of Ukraine on the European Crohn’s and Colitis Organization (ECCO), as well as a member

of the European Association of Urologists’ Scientific Committee.

We cover clinical instances as well as in-depth discussions of the molecular and cellular mechanisms underlying these real-world

issues.