Incretin Biology A Practical Guide : GLP 1 and GIP Physiology

Incretin Biology A Practical Guide : GLP 1 and GIP Physiology

by Sagen Zac-Varghese and Guy A. Rutter

Obesity and diabetes are a 21st century epidemic whose treatment accounts for a sizeable portion of the expense of healthcare globally . Therefore , there is an urgent need for new and improved therapies . Short peptide hormones called incretins are released by the gut in response to meal absorption .

These hormones affect a wide range of physiological functions, including glucose balance, body weight and food intake . This is one of the areas of diabetes research that is expanding the quickest , and during the past ten years , a growing number of innovative diabetic medications , many of which are based on incretin action , have been added to the treatment toolbox .

The book examines the release of incretins at the cellular level from entero-endocrine cells and their effects on the pancreas (alpha and beta cells) and brain after a historical overview of incretin therapies , their discovery and therapeutic uses . The alterations in incretins associated with diabetes and after bariatric surgery are next examined. Finally , a discussion on incretin therapy’s side effects is held .

Importantly , each chapter includes a methodology part that covers from fundamental laboratory research to clinical practice and aims to provide a practical reference to major approaches in the field of incretin biology . By bringing together researchers , medical professionals and bariatric surgeons , Incretin Biology A Practical Guide provides a distinctive viewpoint within this area of study . As a result , it is a thorough text that provides a thorough review of the subject .

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