The Role Of Reactive Oxygen Species In Health And Disease (Original PDF From Publisher)

The Role Of Reactive Oxygen Species In Health And Disease (Original PDF From Publisher)

Written by Frank Columbus

Reactive oxygen species or ROS, are crucial for a variety of biological processes, from physiological regulation mechanisms to harmful

modifications linked to the etiology of an increasing number of diseases in humans.

ROS are metabolic byproducts of many different types of cells, but the endoplasmic reticulum and mitochondria, two essential cellular

organelles, are directly involved in the synthesis and metabolism of ROS.

Overabundance of reactive oxygen species (ROS) within cells can harm proteins, nucleic acids, lipids, membranes, and organelles.

This can trigger cell death mechanisms such apoptosis.

The carefully controlled process of apoptosis is necessary for the growth and survival of multicellular organisms.

These creatures frequently have to get rid of unnecessary or potentially dangerous cells, have mutations build up in them or get

infected with diseases.

Apoptosis, in which cells go through a series of self-destruction events, is characterized by a unique set of morphological and

molecular characteristics.

Thus, preserving regular cellular homeostasis requires effective apoptosis regulation.

The primary mechanisms of apoptosis, which are mediated by mitochondria, death receptors, and endoplasmic reticulum (ER) stress,

are regulated by mitochondrial ROS (mtROS).

With a focus on metabolic, inflammatory, neurodegenerative and neoplastic disorders in particular, this book examines our current

understanding of the role of ROS in each of these three primary routes of apoptosis in relation to many human diseases.

By utilizing various antioxidants to target ROS in the prevention of non-communicable illnesses, its potential and limitations are also

explored.

Future study is needed to fully understand the role of mtROS in the intricate interactions and crosstalk between these several

apoptotic signaling pathways linked to various human illnesses.