Mixed-Mode Chromatography : Principles , Methods and Applications (Original PDF from Publisher)

Mixed-Mode Chromatography : Principles , Methods and Applications (Original PDF from Publisher)

The technology and uses of mixed-mode chromatography (MMC) are covered in the book .

MMC uses multifunctional stationary phases to exploit at least two modes of interactions (i.e., ionic and hydrophobic) with the analytes , which often results in resolution that is significantly higher than that observed with a single-mode process . This is in contrast to conventional single-mode HPLC , which resolves the analytes primarily based on their ionic or hydrophobic properties .

MMC has evolved over the past two decades into a significant analytical and purification tool in a variety of pharmaceutical and biotechnology applications . Numerous items , including antibiotics , vaccines , proteins , glycoproteins , carbohydrates , nucleic acids and peptides have been analyzed using this method . This book is intended as a reference for graduate students and seasoned scientists in the pharmaceutical and biotechnology disciplines who wish to gain a thorough understanding of this constantly developing technology . Its goal is to present a comprehensive survey of mixed-mode chromatography .

see also : Pharmaceutical Chemistry, 2nd Edition (EPUB)