Chemical Linkers in Antibody-Drug Conjugates (ADCs) (Original PDF from Publisher)

Chemical Linkers in Antibody-Drug Conjugates (ADCs) (Original PDF from Publisher)

A powerful method for the targeted treatment of cancer is the covalent coupling of strong cytotoxic drugs to monoclonal antibodies , or antibody-drug conjugates (ADCs) .

Clearly , the clinical utility of an ADC depends on both the monoclonal antibody and the cytotoxic payload , both of which have received considerable study. Though it is frequently overlooked in discussions about ADC design , the structural component bridging the two—the chemical linker—also plays a crucial role in an ADC’s mode-of-action , efficacy , pharmacokinetics, and safety profile .

Chemical Linkers in Antibody-Drug Conjugates seeks to illuminate in great depth the different important characteristics of chemical linkers in ADCs, including drug-to-antibody ratio , stability , payload release mechanism , pharmacokinetics , stability determination , efficacy and safety . This book offers a thorough explanation of the linkers used in ADCs (clinical and late preclinical) , insight into key quality attributes of linkers for ADCs and assists the reader in comprehending the role of linker chemistry and designing new ADCs . It is ideal for postgraduate students and active researchers in drug discovery and development .

Chemical Linkers in Antibody-Drug Conjugates (ADCs) (Original PDF from Publisher)

see also : Tietz Textbook of Laboratory Medicine (Tietz Textbook of Clinical Chemistry and Molecular Diagnostics), 7th Edition (EPUB)