Non-coding Rna Transcripts in Cancer Therapy : Pre clinical and Clinical Implications (Original PDF from Publisher)

Non-coding Rna Transcripts in Cancer Therapy : Pre clinical and Clinical Implications (Original PDF from Publisher)

via Gautam Sethi

A fresh understanding of the function of non-coding RNA molecules, such as microRNAs , long non-coding RNAs and circular RNAs in cancer is provided by the book “Non-coding RNA Transcripts in Cancer Therapy : Pre-clinical and Clinical Implications .

” Focusing on cancer is necessary since it is the second biggest cause of mortality worldwide , behind cardiovascular illnesses and it causes a high number of deaths . The fundamental knowledge and understanding of ncRNAs , their biosynthesis and their biological activities are discussed in the current book .

It has been demonstrated that ncRNAs can control the transcriptional and post-transcriptional levels of gene expression , making them important participants in biological pathways . The effects of ncRNAs’ modulation of molecular pathways on significant molecular mechanisms like proliferation , metastasis , the epithelial-to-mesenchymal transition , apoptosis and autophagy are then discussed . For the purpose of treating cancer , all of these factors are combined .

The production of miRNAs and their biological roles in physiological settings are explained . Next, the effects of miRNAs on growth , metastasis and therapeutic response (drug and radiation resistance) are discussed . The similar procedure is used for lncRNAs and circRNAs and their biosynthesis and functional roles in cells are discussed . The role of lncRNAs and circRNAs in controlling proliferative , metastasizing and therapeutic response

(chemoresistance and radio-resistance) is introduced in the next stage . The function of exosomal ncRNAs in the diagnosis and prognosis of cancer patients is presented in order to widen the scope of the book and add depth to the discussion of these topics , which is based on pre-clinical investigations .

See Also : Advanced Statistics for Health Research (Original PDF from Publisher)

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