Inducing Targeted Protein Degradation : From Chemical Biology To Drug Discovery And Clinical Applications (EPUB)

Inducing Targeted Protein Degradation : From Chemical Biology To Drug Discovery And Clinical Applications (EPUB)

Written by Philipp Cromm

Bringing About Targeted Protein Breakdown

allows researchers and industry drug developers to use induced protein degradation to increase the number of therapeutic targets

that are available for use.

Targeted protein degradation has transformed drug discovery with the invention of the PROTAC technology in 2015 and allowed

pharmaceutical companies to create entirely new treatments.

With a view toward increasing the druggable space, Inducing Targeted Protein Degradation is a timely guide to negotiating the

complexity of the subject and comprehending its practical application.

Readers can discover the most updated details on the following topics in Inducing Targeted Protein Degradation: Targeted protein

breakdown mechanisms in cells and how they are now used to find new drugs A comparison of various methods for inducing

degradation, such as molecular glues, ATTECs, LYTACs, and PROTACs, in addition to further post translational alterations Aspects of

drug development including DMPK optimization and clinical candidate selection criteria An examination of how targeted

deterioration might increase the area that can be drugged For professionals working in drug development and chemical biology

research, Inducing Targeted Protein breakdown will be a useful resource on induced protein breakdown.

See Also : Inducing Targeted Protein Degradation : From Chemical Biology To Drug Discovery And Clinical Applications (Original PDF From Publisher)