Immunomodulatory Biomaterials : Regulating the Immune Response with Biomaterials to Affect Clinical Outcome (Original PDF from Publisher)

Immunomodulatory Biomaterials : Regulating the Immune Response with Biomaterials to Affect Clinical Outcome (Original PDF from Publisher)

authored by Stephen F. Badylak

Biomaterials have been used for thousands of years as mechanical replacements for damaged or diseased tissues .

The fundamental goal of biomaterial design has moved significantly from structural support to designs that elicit an integrated local tissue response and a pro-repair immune cell phenotype . For materials scientists , tissue engineers and others involved in regenerative medicine , Immunomodulatory Biomaterials : Regulating the Immune Response with Biomaterials to Affect Clinical Outcome provides a single , complete reference on biomaterials for modulation of the host response .

In order to promote targeted local cell infiltration and tissue deposition and to control the host immune response after surgical implantation , this book describes techniques , materials and tactics . Our understanding of the function of the immune system , both innate and adaptive , has undergone a significant transformation . Examples of these changes include the recognition of the plasticity of immune cells , particularly macrophages , the interaction between the immune system and stem cells and the requirement for in situ transition between inflammatory and regulatory immune cell phenotypes .

Astonishing progress is being made in the application of these discoveries and the creation of novel biomaterials . There isn’t a book written specifically about the transdisciplinary principles governing the creation , development and therapeutic application of biomaterials that actively control the immunological response of the host tissue . It has never been more difficult for regulators , business and academia to promote innovation while ensuring safety and maximizing efficacy .

This book will show to be an invaluable single resource across disciplines given the extremely multidisciplinary requirements for the design , production and use of immunomodulatory biomaterials . includes all aspects of the development , production , testing and clinical application of biomaterials that actively control the immune response of host tissue . a single resource for comprehending and using the host reaction in the design of biomaterials . An international partnership of top experts in the industry that provides fresh perspective on this rapidly expanding field .

See also : Biocybernetics and Biomedical Engineering – Current Trends and Challenges : Proceedings of the 22nd Polish Conference on Biocybernetics and Biomedical Engineering, Warsaw, Poland, May 19-21, 2021 (Original PDF from Publisher)