Allosteric Modulation Of G Protein-Coupled Receptors (Original PDF From Publisher)

Allosteric Modulation Of G Protein-Coupled Receptors (Original PDF From Publisher)

Written by Robert Laprairie

G protein-coupled receptors (GPCRs) and allosteric modulation are reviewed in depth in Allosteric Modulation of G Protein-Coupled Receptors. Original

research in the field is presented, and the book as a whole offers a thorough explanation of the main problems with GPCR allosteric modulation.

The book introduces the most significant developments and research in the field while also providing background information on fundamental ideas in molecular

pharmacology.

It also covers important techniques.

For researchers and advanced students involved in training and research in pharmacology, toxicology, and pharmaceutical sciences, this book is indispensable.

In particular, many of the GPCR-targeted medications that have been on the market for the last ten years have operated through allostery.

Allosteric modulators modify GPCR-dependent signaling at a position different from the endogenous ligand, in contrast to direct orthosteric-acting substances

that occupy a receptor site comparable to that of endogenous ligands.

Our comprehension of GPCR signaling processes has been increased due to recent methodological and analytical developments.

Unlike what we previously thought, allostery is a common regulation mechanism for all GPCRs, not just a few specific receptor subfamilies.

provides background information on fundamental ideas in molecular pharmacology, such as GPCR-dependent signal transduction, statistical analysis, non

linear regression, complicated models and allosteric modulation.

Examines significant developments and ground-breaking research, such as findings in GPCR allosteric modulation, and discusses them.

The significance of these findings for positive and negative regulation, protein-protein interactions and small-molecule drug discovery is discussed.

contains important techniques for researching allosteric modulation in drug development and characterization at the in vitro, in silico, and in vivo stages.